منابع مشابه
Genetic Association Mapping via Evolution-Based Clustering of Haplotypes
Multilocus analysis of single nucleotide polymorphism haplotypes is a promising approach to dissecting the genetic basis of complex diseases. We propose a coalescent-based model for association mapping that potentially increases the power to detect disease-susceptibility variants in genetic association studies. The approach uses Bayesian partition modelling to cluster haplotypes with similar di...
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abstract because of the many geopolitical, geo economical and geo strategically potentials and communicational capabilities of eco region, members can expand the convergence and the integration in base of this organization that have important impact on members development and expanding peace in international and regional level. based on quality analyzing of library findings and experts interv...
15 صفحه اولGenomic evolution in domestic cattle: ancestral haplotypes and healthy beef.
We have identified numerous Ancestral Haplotypes encoding a 14-Mb region of Bota C19. Three are frequent in Simmental, Angus and Wagyu and have been conserved since common progenitor populations. Others are more relevant to the differences between these 3 breeds including fat content and distribution in muscle. SREBF1 and Growth Hormone, which have been implicated in the production of healthy b...
متن کاملA method for inferring evolutionary relationships among haplotypes, exemplified by haplotypes at the monoamine oxidase locus
In the search for genetic variants affecting liability to complex diseases, haplotype data have received increasing recognition. When there are more than a few haplotypes, one way to assess the association between disease status and haplotypes is to reconstruct their evolutionary history. To achieve that goal, we combine information from two sources: (1) the inferred network relating haplotypes...
متن کاملSimultaneous inference of haplotypes and alleles at a causal gene
We present a methodology which jointly infers haplotypes and the causal alleles at a gene influencing a given trait. Often in human genetic studies, the available data consists of genotypes (series of genetic markers along the chromosomes) and a phenotype. However, for many genetic analyses, one needs haplotypes instead of genotypes. Our methodology is not only able to estimate haplotypes condi...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2010
ISSN: 1474-760X
DOI: 10.1186/gb-2010-11-s1-p20